PubMed · 2026-05-22
Researchers reviewed how imbalances in gut bacteria contribute to osteoporosis by disrupting immune function, nutrient absorption, and bone remodeling — and identified gut-targeting therapies like probiotics and plant-based compounds as promising new treatment directions.
Gut microbiota dysbiosis drives osteoporosis through at least five interconnected mechanisms: immune disruption, altered metabolites, impaired nutrient absorption, endocrine disruption, and inflammation from a leaky gut barrier.
Microbiota-targeted interventions — including probiotics, prebiotics, fecal microbiota transplantation, and natural bioactive plant compounds — show therapeutic promise for preventing and managing osteoporosis.
Traditional Chinese medicine and nanomaterials are emerging as novel delivery strategies for reshaping the gut microbiome to support bone remodeling homeostasis.