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Neuroprotective effects of Uncaria rhynchophylla alkaloid extracts against amyloid-β toxicity via regulation of oxidative stress pathways.
PubMed · 2026-05-28
Researchers found that alkaloid extracts from the medicinal vine Uncaria rhynchophylla (cat's claw vine) protect brain cells from the toxic protein clumps associated with Alzheimer's disease, working through multiple pathways including boosting the body's own antioxidant defenses.
1
Alkaloid extracts from Uncaria rhynchophylla significantly delayed paralysis in transgenic C. elegans worms modeling Alzheimer's amyloid-β toxicity
2
Treatment reduced markers of oxidative damage (ROS, MDA, lipofuscin) while increasing antioxidant enzyme activity (SOD and CAT) in treated worms
3
Extracts suppressed the p38 MAPK stress-signaling pathway and modulated genes involved in protein cleanup (proteasome function) and amyloid metabolism