wound-healing
Wound-healing in plants refers to the biological mechanisms by which plants repair and regenerate tissue damage caused by injury or environmental stress. This is critical to plant science as it reveals how plants defend against pathogenic infection and recover from damage, directly affecting agricultural productivity and plant survival. Understanding these processes provides insights into plant physiology and resilience in facing various environmental challenges.
open_in_new WikipediaPubMed · 2026-05-27
Researchers found that a gel made from the medicinal plant Cayratia japonica significantly sped up wound healing after anal fistula surgery, and traced the key mechanism to a plant compound called Luteolin 7-glucuronide that activates a protein (BMP4) driving tissue repair.
CJH hydrogel achieved a wound healing rate of 68.5% vs 45.2% in controls (P < 0.001) and shortened recovery time in a randomized controlled trial of 81 patients.
Multi-omics analysis identified three stage-specific hub genes in human wound healing: OASL (acute immune phase), TIMP3 (early repair), and BMP4 (remodeling phase).
Luteolin 7-glucuronide, a flavonoid compound in Cayratia japonica, binds BMP4 protein with a docking energy of -8.2 kcal/mol, enhancing its thermal stability and activating downstream Smad signaling to boost fibroblast proliferation.
