Midlife women who substitute cannabis for prescription anxiety or depression medications are more likely to have sleep problems and higher alcohol use. Those replacing antidepressants specifically also tend to experience loneliness and have lower education levels.
1
Sleep difficulties were the strongest predictor of cannabis substitution: 4.2x more likely for anxiety meds (95% CI: 2.1-8.0) and 6.6x more likely for depression meds (95% CI: 3.1-14.1).
2
Alcohol use predicted substitution in both groups (OR ~1.1), and loneliness doubled the odds of substituting for antidepressants (OR = 2.0).
3
Participants showed clinically significant anxiety (mean score 12.5) and depression (mean score 11.6), with average adverse childhood experience scores above 4 in both groups.
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