Scientists built a lab-grown three-layer blood vessel using human cells to study Hutchinson-Gilford progeria, a rare rapid-aging disease, and found that fibroblasts (the vessel's structural cells) play an outsized role in driving the disease's hallmark artery damage.
1
A trilayer tissue-engineered blood vessel (TEBV) combining smooth muscle cells, endothelial cells, and fibroblasts was used to model Hutchinson-Gilford progeria syndrome (HGPS)
2
HGPS fibroblasts specifically drove extracellular matrix dysregulation and fibrotic signaling, while smooth muscle cells drove collagen buildup and endothelial cells drove inflammation
3
Base editing to correct the HGPS mutation restored many disease features in the engineered vessels to near-healthy levels
mail
Weekly plant science — one email, Saturdays.
Check your inbox to confirm — link expires in 24 hours.
Something went wrong — please try again.
Too many signup attempts from your network. Try again in an hour, or email hello@plant.news.