PubMed · 2026-03-27
A sweeping review of 20 years of global research reveals that plant extracts are a growing and highly collaborative scientific frontier in the fight against drug-resistant 'superbug' staph infections, with Asia — particularly China and India — now leading the world in output and the field rapidly advancing toward sophisticated new delivery methods.
1,468 publications across 535 journals were analyzed over 20 years, showing rapid growth in the field, with Asia dominating output (China: 526 publications, India: 427).
Research has evolved through four distinct phases, culminating in a frontier focused on nanoformulations and dual-action strategies that fight both infection and inflammation simultaneously.
The field is highly collaborative, averaging 6.35 authors per paper with 27.52% international co-authorships and strong citation impact at 28.18 citations per document — yet a significant gap remains between lab findings and actual clinical medicines.