Scientists extracted a tiny sugar molecule from the stems and leaves of Siberian Solomon's Seal — parts usually discarded after rhizome harvest — and found it reversed depression-like behavior in stressed mice by rebalancing gut bacteria and boosting serotonin production.
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A 4.287 kDa fructan polysaccharide (PSLP-1) isolated from Siberian Solomon's Seal stems and leaves significantly reduced immobility time in both the forced swim and tail suspension tests in chronically stressed mice
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PSLP-1 suppressed the IDO1-mediated kynurenine pathway (linked to inflammation-driven depression) while promoting tryptophan hydroxylase activity to increase serotonin (5-HT) synthesis
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PSLP-1 remodeled gut microbiota by increasing Akkermansia (a gut-barrier-protecting bacterium) and decreasing Lactobacillus and Alistipes
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