A water extract from the shaggy bracket fungus helped reverse PCOS-like symptoms in rats by calming inflamed ovarian cells, correcting hormone levels, and reshaping gut bacteria, offering a possible lead for future PCOS treatments.
1
WE normalized estradiol, testosterone, and LH levels, and corrected the elevated LH/FSH ratio seen in PCOS rats
2
WE restored gut microbiota diversity and corrected the Firmicutes/Bacteroidetes ratio linked to metabolic dysbiosis
3
WE inhibited ovarian ferroptosis by downregulating ACSL4, HIF-1α, and TFRC while upregulating the protective protein GPX4
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