cancer-biology
Cancer biology is the study of uncontrolled cell growth and tumor development mechanisms. In plant science, this field is relevant for understanding pathological growth responses and disease-induced cellular abnormalities, such as tumor-like formations caused by pathogens. Plant cancer research provides insights into cellular regulation, division control, and how organisms have evolved resistance to aberrant growth.
PubMed · 2026-05-01
This review explains how excess body fat and poor diet drive endometrial cancer by disrupting hormone levels, insulin signaling, and inflammation — a convergence of metabolic failures that reprograms cells toward uncontrolled growth.
Aromatase enzymes in enlarged fat cells convert androgens into estradiol, directly fueling estrogen-receptor-driven cell proliferation in the uterine lining.
Hyperinsulinemia and IGF-1 signaling independently activate PI3K/AKT/mTOR and RAS/MAPK pathways, accelerating cell division while suppressing tumor-suppressive checkpoints.
Obesity shifts adipokine balance — raising pro-inflammatory leptin/JAK2-STAT3 signaling and lowering protective adiponectin/AMPK signaling — promoting epithelial-mesenchymal transition and chronic inflammation.