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PRMT1 drives cervical cancer progression by orchestrating cell growth, migration, and angiogenesis.
PubMed · 2026-06-09
Researchers found that a protein called PRMT1 helps cervical cancer grow, spread, and form new blood vessels. Removing it in lab and animal models slowed tumor growth significantly.
1
PRMT1 was elevated in cervical cancer tissue and correlated with higher tumor grade and lymph node metastasis, though not with overall survival
2
Knocking out PRMT1 in HeLa cells inhibited proliferation, colony formation, and migration while triggering cell death and arresting cells in the S-phase of division
3
In live animal (xenograft) models, PRMT1 knockout significantly reduced tumor growth and lowered markers of cell division (Ki-67) and blood vessel formation (CD31)