cancer-biology
Cancer biology is the study of uncontrolled cell growth and tumor development mechanisms. In plant science, this field is relevant for understanding pathological growth responses and disease-induced cellular abnormalities, such as tumor-like formations caused by pathogens. Plant cancer research provides insights into cellular regulation, division control, and how organisms have evolved resistance to aberrant growth.
PubMed · 2026-03-25
Researchers discovered that amentoflavone, a natural compound from Ginkgo biloba, can prevent lung cancer from spreading by blocking a key protein involved in cancer cell migration. Laboratory and animal studies show the plant-derived compound successfully stopped cancer metastasis without the severe side effects typical of conventional treatments.
Machine learning model achieved 95.1% accuracy (AUC 0.951) on internal testing and 81.4% accuracy (AUC 0.814) on external validation, demonstrating robust predictive power for target identification
Amentoflavone reduced lung cancer cell migration by downregulating TGFBR2 protein and inhibiting Smad2/3 phosphorylation, effectively reversing epithelial-mesenchymal transition (EMT)
In vivo mouse studies confirmed AMF suppressed pulmonary metastasis by dampening the TGF-β/Smad signaling pathway, with no significant toxicity observed
