Association between dietary intakes and gut microbiota composition in individuals with Lynch syndrome: a cross-sectional analysis of the AAS-Lynch study.
Demaré N, Bridier-Nahmias A, Carbonnelle E, Magnan M, Bellicha A
Gut Microbiome
Every tomato, bean, and leafy green you grow and eat is quietly feeding a community of gut bacteria that research increasingly links to cancer protection — and this study shows the plant-to-animal protein ratio in your diet may be one of the most important levers you control.
Scientists studied 95 people with a genetic condition that raises colorectal cancer risk and found that those who ate more plant-based foods had a richer, more varied community of gut bacteria. Red meat, saturated fat, and typical Western eating habits were tied to a less diverse gut microbiome. One type of beneficial gut bacteria in particular thrived in people who ate more plant protein.
Key Findings
Higher plant protein intake and a greater ratio of plant-to-animal protein were positively associated with gut microbiota alpha-diversity (Shannon and Simpson indices) in 95 Lynch syndrome patients.
Western dietary patterns, red meat, saturated fatty acids, cholesterol, and animal proteins were all negatively associated with gut microbial diversity.
Plant protein intake was specifically linked to higher relative abundance of Lachnospiraceae_NK3A20_group, a bacterial family associated with gut health.
chevron_right Technical Summary
In people with a hereditary cancer syndrome, eating more plant proteins and fewer animal products was linked to greater diversity of beneficial gut bacteria, while Western-style diets high in red meat and saturated fat were linked to reduced microbial diversity.
Abstract Preview
People with Lynch syndrome (LS) have a high probability of early onset of several cancers, mainly colorectal cancer (CRC), due to genetic alterations. Gut microbiota alteration has been associated ...
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