Plant-derived nanovesicles: the intelligent nanoplatforms for therapeutics and drug delivery.
Du S, Jia D, Liang G, Dou Y
Plant Signaling
Vegetables, fruits, and herbs you grow or eat may be producing microscopic particles that actively interact with your body's cells in ways scientists are only beginning to understand — and those same particles could someday replace harsher synthetic drug carriers.
Plants constantly release incredibly tiny, bubble-like particles packed with biological molecules. Scientists have discovered that these particles can travel into the human body, slip inside our cells, and change how those cells behave — sometimes fighting inflammation or slowing tumor growth. Researchers are now reviewing everything known about these particles, from how plants make them to how they might be used as natural medicines with fewer side effects than conventional drugs.
Key Findings
Plant-derived nanovesicles (PDNVs) demonstrate low immunogenicity and high biocompatibility, making them safer candidates for drug delivery than many synthetic nanoparticles.
PDNVs have shown therapeutic potential across a broad range of conditions including cancer, inflammation, viral infections, liver disorders, brain disorders, osteoporosis, and tissue regeneration.
PDNVs can be isolated from a wide variety of plant sources, and the review documents their full lifecycle from biogenesis and purification through routes of administration and biodistribution in vivo.
chevron_right Technical Summary
Tiny vesicles naturally produced by plants carry bioactive molecules that can enter the human body and influence disease. This review synthesizes current research showing these plant-derived nanovesicles could become a new class of low-toxicity drug delivery vehicles and treatments for cancer, inflammation, and liver and brain disorders.
Abstract Preview
Extracellular vesicles (EVs) are cell-secreted phospholipid bilayer vesicles that play a key role in intercellular communication by transporting molecular cargo and engaging in surface-level signal...
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