Polyphenol-Rich Coffee Leaf Extract Alleviates High-Fat Diet-Induced Intestinal Barrier Dysfunction through Modulation of Barrier Integrity, Enterohepatic Axis, and Gut Microbiota.
Mei S, Cao Q, Huang G, Chen D, Kitts DD
Summary
PubMedA polyphenol-rich extract from coffee leaves reduced weight gain and inflammation in mice on high-fat diets by strengthening gut barrier function and improving liver health, suggesting coffee leaf compounds may prevent diet-related metabolic disease through changes to gut bacteria and bile acid metabolism.
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Key Findings
WEAC supplementation at 100-200 mg/kg reduced body weight, serum TNF-α, and inflammatory markers across multiple tissues (colon, liver, brain)
Improved intestinal barrier integrity through upregulation of tight-junction proteins and 50%+ reduction in intestinal permeability markers
Decreased hepatic lipid accumulation and improved lipid profiles (reduced triglycerides, total cholesterol, and LDL cholesterol levels)
Original Abstract
A polyphenol-rich extract (WEAC) from coffee leaf was previously shown to protect the epithelial barrier integrity. This study investigated the protective effects of WEAC in C57BL/6 mice fed a high-fat diet (HFD). WEAC supplementation (100-200 mg/kg·bw) reduced body weight and lowered TNF-α levels in serum, colon, liver, and brain in mice. WEAC improved mouse intestinal barrier integrity by upregulating the tight-junction protein and reducing intestinal d-lactic acid leakage. Liver histology revealed reduced lipid accumulation and ballooning degeneration, corresponding to decreased triglyceride, total cholesterol, and low-density lipoprotein cholesterol levels. The WEAC intervention also decreased total bile acid levels and altered short-chain fatty acid profiles and key phytochemical metabolism. Furthermore, WEAC reduced the
This connects to 9 other discoveries — 1 species, 5 topics, 3 related articles
Species Mentioned
Coffee is a beverage brewed from roasted, ground coffee beans. Darkly colored, bitter, and slightly acidic, coffee has a stimulating effect on humans, primarily due to its caffeine content, but decaffeinated coffee is also commercially available. There are also various coffee substitutes.
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