Europe PMC · 2026-07-03
This review consolidates what scientists know about nux vomica (Strychnos nux-vomica), the seed behind one of history's most notorious plant poisons, finding it holds real promise for treating nerve disorders, heart arrhythmias, pain, inflammation, and cancer. The authors flag that research is still mostly lab-based, safety risks from the plant's toxins remain underexplored, and clinical use demands much more rigorous investigation.
Semen Strychni extracts and isolated compounds show activity across at least five pharmacological areas: nervous system diseases, cardiac arrhythmia, analgesia, inflammation, and antitumor effects.
Nearly all current evidence comes from in vitro (cell/tissue) experiments; systematic comparison of different extracts and purified compounds in living subjects is largely absent.
Significant toxicity risks persist both before and after traditional processing of the seeds, and the underlying mechanisms of that toxicity are not yet well characterized.
