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DNA sequencing is the process of determining the precise order of nucleotides in a DNA molecule, enabling researchers to read the genetic code of any organism. In plant science, sequencing technologies have revolutionized our understanding of plant genomes, allowing scientists to identify genes responsible for traits like drought tolerance, disease resistance, and yield. These insights accelerate crop improvement, evolutionary studies, and the discovery of novel biochemical pathways unique to the plant kingdom.

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Exploring the oral microbiome: from traditional techniques to advanced omics and databases.

PubMed · 2026-05-06

This minireview surveys the molecular and bioinformatic tools used to study the oral microbiome — the community of bacteria, fungi, and protists living in the human mouth — and highlights key databases that catalog this microbial diversity. It covers sequencing techniques and omics approaches that help researchers link specific microbes to dental disease and oral cancer.

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16S rRNA gene sequencing is the primary method for profiling bacterial species in the oral cavity, including pathogens linked to cavities, gum disease, and oral cancer.

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18S rRNA gene sequencing complements bacterial analysis by revealing fungal and protist members of the oral microbiome, including parasites.

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Dedicated databases such as the Human Oral Microbiome Database (HOMD) and Oral Microbiome Database (OMD) provide curated reference data that accelerate community-level research.

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