PubMed · 2026-05-29
A study found that giving infants their own pre-antibiotic stool back as a transplant helped restore their gut bacteria and metabolism after antibiotic treatment, while infants who didn't receive the transplant stayed disrupted for longer.
Amoxicillin treatment in infants caused measurable disruption to gut microbial communities, increased antibiotic resistance genes, and altered metabolites including short-chain fatty acids and bile acids.
The infant who did NOT receive the autologous fecal transplant showed persistently altered microbiome composition and antibiotic resistance gene profiles throughout the follow-up period.
The infant who received their own pre-antibiotic stool back showed convergence toward pre-antibiotic microbial community structure and reduction of antibiotic resistance genes including β-lactam and tetracycline resistance genes.