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plastic-biodegradation

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Catalytic mechanisms, engineering, and cascade biocatalysis of mono(2-hydroxyethyl) terephthalate hydrolases for efficient PET depolymerization: A review.

PubMed · 2026-04-15

Scientists are developing better enzymatic tools to break down plastic water bottles and food containers into reusable chemical building blocks, getting closer to truly circular plastic recycling.

1

A bottleneck compound called MHET accumulates during plastic breakdown and blocks the enzymes doing the work — new MHET hydrolase enzymes solve this specific problem

2

The bacterium Ideonella sakaiensis produces a key enzyme (IsMHETase) whose structure and catalytic mechanism have now been mapped in detail, enabling targeted protein engineering

3

Combining PET-degrading and MHET-degrading enzymes in a coordinated two-step cascade system significantly improves complete depolymerization efficiency compared to either enzyme alone