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Polyethylene and polystyrene oxidation by host and microbial oxidoreductases in Zophobas atratus.

PubMed · 2026-05-11

Scientists discovered that superworms (Zophobas atratus) break down common plastics using both their own body enzymes and gut bacteria. A host enzyme called CYP6k1-ZP10 attacks polyethylene, while a gut microbe, Klebsiella variicola, uses its own enzyme to oxidize both polyethylene and polystyrene.

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Zophobas atratus larvae showed significantly higher ingestion and oxidation of both polyethylene and polystyrene compared to wax moth larvae (Galleria mellonella)

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Antibiotic treatment substantially reduced plastic oxidation but did not eliminate it, proving that both the host insect and its gut microbes each contribute independently to plastic breakdown

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A host enzyme (CYP6k1-ZP10) was confirmed to oxidize polyethylene via RNA interference, while the gut bacterium Klebsiella variicola and its FMN-dependent monooxygenase were identified as responsible for oxidizing both plastics

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