neuroinflammation-research
Neuroinflammation-research studies inflammatory signaling cascades triggered by pathogens and environmental stressors in biological systems. In plant science, this research framework examines how plants mount inflammatory-like cellular responses through their signaling networks to defend against pathogenic threats and stress conditions. Understanding these inflammatory mechanisms is important for elucidating plant immunity mechanisms and developing strategies to enhance crop resilience and disease resistance.
PubMed · 2026-05-16
Researchers found that flavonoids extracted from the medicinal plant Epimedium brevicornu (horny goat weed) reduced brain inflammation and Alzheimer's-like symptoms in mice, working through multiple biological pathways simultaneously.
127 compounds were identified in the Epimedium extract; 45 reached the bloodstream and 38 crossed into the brain after oral dosing
EF pretreatment for 14 days significantly improved cognitive performance in LPS-treated mice across open field, Y-maze, and Morris water maze tests
Key active compounds bound target proteins with strong affinity (below -6.2 kcal/mol), acting via PI3K/AKT and cGAS-STING signaling pathways to reduce amyloid-β accumulation and tau phosphorylation
