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Bioinformatic and experimental analyses revealed pathogen-derived pathoPEP candidates predicted to control plant miRNA expression and infection.
PubMed · 2026-05-18
Researchers discovered that plant pathogens may produce tiny peptides that hijack the plant's own gene-silencing system, effectively using the plant's molecular machinery against itself to suppress immune responses and promote infection.
1
Pathogens appear to produce short peptides (called pathoPEPs) that mimic plant-native miPEPs, potentially hijacking the plant's microRNA gene-regulation system
2
Bioinformatic analysis identified multiple candidate pathoPEP sequences across pathogen genomes that share significant homology with host miPEP sequences
3
Experimental analyses supported the hypothesis that these pathogen-derived peptides can modulate host microRNA expression, suggesting a novel mechanism of host manipulation