PEITC, a natural compound found in cruciferous plants like watercress and horseradish, blocks a key inflammatory chain reaction in brain immune cells activated by viral-like signals. In both cell cultures and mice, it reduced damaging inflammation and guided immune cells toward a protective, healing state.
1
PEITC pre-treatment significantly reduced pro-inflammatory markers including TNF-α, IL-1β, IL-6, and nitric oxide in microglial cells stimulated with a viral mimic (poly I:C)
2
PEITC suppressed TLR3, NF-κB (p65), MAPK, and JAK/STAT signaling pathways while boosting TRAF3, a key promoter of antiviral defense
3
In mice with induced neuroinflammation, PEITC reduced Iba1 expression and shifted microglia from the pro-inflammatory M1 phenotype to the anti-inflammatory M2 phenotype
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