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Scientists breed wheat with far less gluten in one generation
PubMed · 2026-07-29
Scientists combined two gene-editing tools with a wheat breeding shortcut to create wheat lines with over 70% less of the gluten protein fragments that trigger celiac disease, while keeping the wheat's baking quality and kernel size intact.
1
Some doubled haploid lines showed more than 70% reduction in immunogenic epitopes within alpha-gliadin proteins, outperforming both parent lines
2
Combining RNAi silencing with CRISPR editing nearly depleted gliadins in some lines, with compensatory increases in high-molecular-weight glutenin subunits important for bread-making quality
3
Kernel size and specific weight traits were largely preserved despite the major protein composition changes
