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Kinesin ARK2 coordinates PIN2 trafficking and nanoclustering to mediate root gravitropism in Arabidopsis.
PubMed · 2026-05-22
Scientists discovered a molecular motor protein called ARK2 that helps roots grow downward in response to gravity by controlling how a key hormone-transport protein moves around and clusters within plant cells.
1
ARK2 kinesin promotes vesicle trafficking of PIN2 along microtubules to maintain PIN2 abundance at the plasma membrane during gravitropic response.
2
ARK2 directly interacts with PIN2 to promote its assembly into nanoclusters and restrict its lateral diffusion within the plasma membrane.
3
Both functions together sustain the asymmetric polar distribution of PIN2 required for auxin gradient formation and directional root growth.
