PubMed · 2026-09-01
Researchers engineered a wearable patch that uses nanoparticles derived from medicinal plants to deliver a chemotherapy drug and genetic regulators directly to aggressive breast cancer tumors, improving targeting precision while reducing toxic side effects.
Plant-derived exosomes acted as biocompatible carriers, enabling cascade tumor targeting that concentrated the drug payload at the tumor site rather than throughout the body
Combining plant exosomes, miRNA gene regulators, and cisplatin chemotherapy produced a synergistic anti-tumor effect greater than any single agent alone
The microneedle wearable platform demonstrated high safety in models of triple-negative breast cancer, a subtype that currently has very limited targeted treatment options