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Dormant viral DNA in our genome may predict cancer survival

OpenAlex · 2026-08-20

Researchers reviewed 11 studies on ancient virus-like DNA fragments buried in the human genome, finding that one type correlates with better immune response and survival in pancreatic cancer patients.

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Analysis pooled 11 studies covering 1,085 pancreatic cancer cases among 9,241 total cancer patients

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HERV detection rates ranged from 16.7% to about 80% depending on the sequence and lab method used

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HERV-H derived HHLA2 was linked to increased CD8+ T-cell infiltration and favorable survival (HR 0.47-0.66), while other markers showed adverse associations (HR 1.26-2.24)

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