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Unveiling the potential of banana (
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Multi-omics and functional analyses in Aesculus wilsonii elucidate the biosynthetic pathways of moretane- and oleanane-type triterpenoids.
PubMed · 2026-04-13
Scientists mapped the genetic blueprints behind how Wilson's horsechestnut tree produces aescin and dozens of other medicinal compounds, discovering a brand-new natural molecule called moretenol along the way.
1
Metabolomic profiling identified 135 triterpenoids across 9 structural types, including one completely new scaffold not previously described in science.
2
Four triterpenoid biosynthetic gene clusters were mapped in the near-complete genome, with two CYP716A enzymes shown to perform distinct chemical reactions on the same starting molecule (β-amyrin).
3
A newly evolved enzyme (AwOSC13) produces moretenol via a previously unknown biosynthetic pathway, confirmed by successfully recreating the pathway in tobacco plants.
