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Plant-Mediated Green Synthesis of Selenium Nanoparticles Using Schinus molle (L.) Leaf Extract: Antimicrobial Activity Against MRSA, Anti-Virulence Properties, and Anticancer Potential.

PubMed · 2026-04-21

Researchers used leaf extract from the Peruvian pepper tree to create tiny selenium particles that effectively kill drug-resistant staph bacteria and show promise against cancer cells — all without harsh chemicals.

1

Selenium nanoparticles (50 nm) made from Peruvian pepper tree extract inhibited all 10 drug-resistant staph (MRSA) strains tested, with effective doses of 8–12 μg/mL

2

Combining the nanoparticles with three common antibiotics produced strong synergy (FICI ≤ 0.5), dramatically lowering the antibiotic doses needed to kill bacteria

3

The nanoparticles selectively killed cancer cells with minimal toxicity to normal cells, and lab tests confirmed they triggered programmed cell death (apoptosis) in cancer lines