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Anti-adipogenic cyathane diterpenoids from Onychium japonicum.

PubMed · 2026-06-23

Researchers isolated 15 natural compounds from a fern used in traditional Zhuang medicine and found all of them can suppress fat cell formation, with six matching the effectiveness of established anti-obesity compounds. Ten of these compounds had never been described before.

1

15 cyathane-type compounds were isolated; 10 were entirely new to science, named onyjaponiods A–J.

2

All 15 compounds reduced fat cell development in lab tests, with 6 performing comparably to the positive controls berberine and resveratrol.

3

This is the first study to document anti-obesity activity in this entire class of plant compounds (cyathane diterpenoids).

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