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alkaloid-profiling

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Traditional Tibetan liver remedy yields 74 alkaloids, eight of them newly discovered

Europe PMC · 2026-07-01

Researchers mapped 74 distinct alkaloid compounds in a Tibetan medicinal plant called Corydalis impatiens, including 8 never described before. These compounds are likely responsible for the plant's traditional use in treating liver disease.

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74 isoquinoline alkaloids were identified across 6 structural classes, including 20 tetrahydroprotoberberines and 19 protoberberines

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8 compounds were tentatively identified as new-to-science alkaloids, all belonging to phthalide isoquinoline or benzylisoquinoline subtypes

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Feature-based molecular networking (FBMN) proved effective for rapidly cataloging complex alkaloid mixtures and flagging novel compounds in crude plant extracts

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