Andean tara plant extract selectively kills mouse colon cancer cells
Medicinal Plants
Tara, a tree grown in the Andes for its tannin-rich seed pods used in food and leather industries, is now being explored as a source of cancer-fighting compounds, showing how everyday crop plants can hold untapped pharmacological potential.
Scientists tested a purified extract from the pods of Caesalpinia spinosa, a South American tree sometimes called tara, against colon cancer cells grown in lab dishes. In mouse cancer cells, the extract made cells self-destruct by flooding them with reactive molecules and switching on their internal death machinery, but it left two human colon cancer cell lines largely unharmed under the same conditions. The researchers say this is early-stage evidence and more work is needed to understand exactly how the extract works and whether it could help as a gentler alternative or add-on to existing chemotherapy drugs.
Key Findings
P2Et extract showed no significant cytotoxicity in human colorectal cancer cell lines SW480 and SW620 under tested conditions
In murine CT26 colon cancer cells, P2Et reduced viability and increased reactive oxygen species and caspase-3/7 activation at 48 hours
No changes in mitochondrial permeability transition pore opening were detected, leaving the exact cell-death mechanism unresolved
chevron_right Technical Summary
An extract from the tara plant (Caesalpinia spinosa) killed mouse colon cancer cells in lab tests by triggering oxidative stress and activating cell-death enzymes, while sparing human colon cancer cells in this study.
Abstract Preview
Original paper
Biological activity of P2Et extract from Caesalpinia spinosa on colorectal cancer cell lines
Colorectal cancer is the third most diagnosed malignancy and the second leading cause of cancer-related mortality worldwide, with approximately 1.9 million new cases and 0.9 million deaths reported...
open_in_new Read full abstractAbstract copyright held by the original publisher.
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Tara spinosa, commonly known as tara (Quechua), also known as Peruvian carob or spiny holdback, is a small leguminous tree or thorny shrub native to Peru. T. spinosa is cultivated as a source of tannins based on a galloylated quinic acid structure. This chemical structure has been confirmed also ...