Herbal fertility tablet shows no toxic effects in rat study
Medicinal Plants
If you've ever wondered whether a plant-based supplement on a store shelf has actually been tested for safety, this study shows what that testing looks like and what 'no toxic effects found' really means in practice.
Researchers gave rats an herbal tablet, made from a mix of traditional Ayurvedic plant ingredients, every day for four weeks at three different strengths, including one much higher than what a person would normally take. The rats stayed healthy: normal weight gain, normal blood tests, and no damage to their organs. The only small blip was a slight uptick in a blood mineral at the highest dose, which the researchers didn't consider a safety concern.
Key Findings
No deaths or treatment-related clinical signs across 40 rats (20 male, 20 female) over 28 days of daily dosing at 225, 450, or 1125 mg/kg/day
No treatment-related abnormalities in body weight, food/water intake, bloodwork, or organ histopathology at any dose
NOAEL (No Observed Adverse Effect Level) established at 1125 mg/kg/day, the highest dose tested, for both sexes; mild serum phosphorus elevation seen only in high-dose satellite animals
chevron_right Technical Summary
A 28-day animal study found that an Ayurvedic herbal tablet marketed for male infertility caused no toxic effects in rats, even at doses more than seven times the human equivalent dose. The only notable finding was a mild, likely minor increase in blood phosphorus at the highest dose.
Abstract Preview
Original paper
SUB-ACUTE ORAL TOXICITY EVALUATION OF GYNOVEDA® BEEHJ AYURVEDIC TABLETS IN WISTAR RATS AS PER OECD TG 407
Background: Gynoveda® BEEHJ Ayurvedic Tablets are an Ayurvedic formulation intended for use in the management of male infertility. As formulations used in fertility management may require repeated ...
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