A High-Fiber, Plant-Based Diet in Myeloma Precursor Disorders: Results from the NUTRIVENTION Clinical Trial and Preclinical Vk*MYC Model.
Shah UA, Cogrossi LL, Garcés JJ, Policastro A, Castro F
Summary
PubMedWhy it matters This matters because the fiber that protects against a blood cancer comes from the same fruits, vegetables, legumes, and whole grains you can grow or buy at a farmers market — making your dinner plate a genuine health intervention.
Researchers tested whether eating more plants and fiber could help people who had an early warning sign for a blood cancer called multiple myeloma. Over 24 weeks, participants who ate a plant-rich, high-fiber diet got healthier in multiple ways — better gut bacteria, less inflammation, and improved metabolism. Experiments in mice confirmed that it's the fiber itself doing the heavy lifting: it feeds gut bacteria that produce protective compounds, which then wake up the immune system to fight off early cancer cells.
chevron_right Technical Details
A clinical trial found that switching to a high-fiber, plant-based diet improved metabolic health, gut microbiome diversity, and immune function in people at risk of developing multiple myeloma — and mouse studies confirmed that fiber alone (not just weight loss) can slow the disease's progression.
Key Findings
23 participants on a high-fiber, plant-based diet for 12–24 weeks showed improvements in BMI, insulin resistance, gut microbiome diversity, and inflammatory markers.
Disease progression stabilized or improved in all participants, with 2 showing a measurable improvement in their precursor disease trajectory.
In mouse models, a high-fiber diet delayed progression to myeloma independent of calorie restriction or weight loss, acting through increased short-chain fatty acid production that boosted antitumor immunity.
Abstract Preview
Consumption of a Western diet and high body mass index (BMI) are risk factors for progression from premalignant phenotypes to multiple myeloma, a hematologic cancer. In the NUTRIVENTION trial (NCT0...
open_in_new Read full abstract on PubMedAbstract copyright held by the original publisher.
Was this useful?
Shared Plant-human Biology: Herbicide Effects and New Biomarkers Perspectives.
This matters because the herbicides sprayed on your lawn, your food crops, and your local park may be quietly disrupting the same biological machinery in you...