A Comprehensive Review on Metabolomics-Guided Metabolite Production in Plant Tissue Culture: Integrating Omics and Synthetic Biology for Enhanced Yields.
Manam M, Srivatsa KS, Mishra A, Paulraj Gundupalli M
Medicinal Plants
Many herbal remedies and plant-derived medicines are limited by slow-growing plants, climate, and geography — but this research framework could make it possible to brew those same compounds in a lab year-round, keeping supplies stable and prices lower.
Plants make thousands of useful chemicals — painkillers, antioxidants, dyes — but growing whole plants is slow and unpredictable. Researchers now want to grow just plant cells in tanks, using advanced molecular tools to read and rewrite the chemical recipes inside those cells. This review lays out how combining detailed chemical fingerprinting with genetic editing tools like CRISPR could turn that idea into a reliable industrial process.
Key Findings
Metabolomics (chemical fingerprinting of cells) can serve as a real-time decision-making tool — not just a measurement — to guide genetic edits and culture conditions toward higher yields of target compounds.
A suite of technologies — including CRISPR pathway editing, synthetic promoters, modular genetic circuits, and bioreactor scale-up — can now be combined under a single 'design-build-test-learn' engineering cycle for plant cell cultures.
Emerging tools such as single-cell metabolomics, digital twin computer models, and real-time biosensors are identified as the next frontier for making plant cell biomanufacturing more predictable and scalable.
chevron_right Technical Summary
Scientists have written a roadmap for turning plant cell cultures into reliable, programmable factories for medicines, nutrients, and industrial compounds — replacing guesswork with data-driven genetic and chemical engineering.
Abstract Preview
The growing bioeconomy demands sustainable platforms for the production of high-value pharmaceuticals, nutraceuticals, and industrial compounds. Plant tissue culture (PTC) is an attractive alternat...
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