Citrus-Derived Exosome-like Nanoparticles Attenuate High-Fat Diet-Aggravated Colitis by Gut Microbiota-Metabolites Modulation.
Zhan M, Zhao C, Han Y, Chen B, Chen Y
Summary
PubMedCitrus nanoparticles help reduce inflammation and restore healthy gut bacteria in mice fed high-fat diets, offering a potential dietary treatment for colitis by healing the intestinal barrier and reducing oxidative stress.
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Key Findings
Citrus-derived exosome-like nanoparticles improved disease activity, colon length, and immune organ index in high-fat diet-induced colitis models
CELNs restored gut barrier integrity by upregulating tight junction proteins occludin and ZO-1
Treatment rebuilt microbial dysbiosis and suppressed oxidative stress and pro-inflammatory signaling pathways
Original Abstract
High-fat diet (HFD) is a recognized risk factor that exacerbates intestinal inflammation and complicates colitis pathology, posing challenges for treatment. This study evaluated citrus-derived exosome-like nanoparticles (CELNs) as a dietary intervention. Results demonstrated that CELNs effectively ameliorated HFD-aggravated colitis, improving the disease activity, colon length, and immune organ index. Mechanistically, CELNs restored gut barrier integrity (upregulating occludin and ZO-1), suppressed oxidative stress and pro-inflammatory signaling, and rebuilt microbial dysbiosis (enriching
This connects to 9 other discoveries — 1 species, 3 topics, 5 related articles
Species Mentioned
Citrus is a genus of flowering trees and shrubs in the family Rutaceae. Plants in the genus produce citrus fruits, such as citrons, mandarins, and pomelos. Many important citrus crops have been developed through extensive hybridization, including oranges, lemons, grapefruits, and limes, all of wh...
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