Polyphenol-Loaded Plant Extracellular Vesicles: A New Approach to Combat AGEs-Induced Neurotoxicity via the Microbiota-Gut-Brain Axis.
Cao Y, Wang R, Ni Z, Luo T, Zhang X
Summary
PubMedPlant-derived nanoparticles loaded with polyphenols could protect the brain from damage caused by foods high in AGEs by preserving the gut-brain connection and reducing neuroinflammation. This approach targets the microbiota-gut-brain axis to prevent age-related neurodegeneration.
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Key Findings
Excessive dietary AGEs impair intestinal barrier function and disrupt gut microbiota homeostasis, triggering neuroinflammation via the microbiota-gut-brain axis
Plant extracellular vesicles enhance polyphenol bioavailability while exhibiting synergistic antioxidant and anti-inflammatory properties
PEV-polyphenol delivery systems could preserve microbiota-gut-brain axis function to mitigate AGEs-induced neurotoxicity and neurodegeneration
Original Abstract
Excessive dietary intake of advanced glycation end products (AGEs) is a potential risk factor for neurodegenerative diseases (NDDs). The underlying mechanism may involve AGEs-induced impairment of intestinal barrier and disturbance of gut microbiota homeostasis, which in turn triggers neuroinflammation and oxidative stress via the microbiota-gut-brain (MGB) axis. Plant extracellular vesicles (PEVs), as natural nanocarriers, can not only enhance the bioavailability of polyphenols but also, in synergy with polyphenols, exhibit antioxidant, anti-inflammatory, and gut-microenvironment-modulating properties. This review summarizes and discusses the potential and mechanisms by which PEVs-polyphenols delivery systems may mitigate AGEs-related neurotoxicity by preserving MGB axis function, thereby providing a theoretical foundation for the development of prospective intervention strategies in this field.
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