Parasitic castration by a viral protein tyrosine phosphatase targeting the host cell cycle checkpoint protein Rad9A.
Gao H, Guo M, Yang X, Hu R, Wu K
Summary
PubMedParasitic wasps use a viral protein to disable a critical cell cycle checkpoint in host insects, preventing them from reproducing and allowing the parasite to hijack the host's reproductive resources—a mechanism that could inform understanding of host manipulation strategies.
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Key Findings
Viral protein tyrosine phosphatase specifically targets Rad9A, a host cell cycle checkpoint protein
This molecular hijacking mechanism enables parasitic castration of host insects
Parasites redirect host reproductive resources to support parasite development
Original Abstract
Parasitic castration is a widespread strategy where parasites hijack host reproductive resources, yet the key molecular mechanisms driving this phenomenon remain poorly understood. Here, we reported that parasitization by the parasitic wasp
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