PubMed · 2026-04-22
Researchers identified bacterial pathways capable of breaking down hydroxyphenylethanones—aromatic chemicals derived from lignin, the tough structural polymer found in all woody plants—and engineered microbes to do it more efficiently. This advances efforts to convert plant waste into renewable chemicals that could replace petroleum-derived products.
A bacterial degradation pathway was identified for hydroxyphenylethanones (HPEs), including acetovanillone, 4-hydroxyacetophenone, and acetosyringone—chemicals abundant in industrial lignin waste streams.
The pathway only partially degrades these lignin-derived aromatic compounds, indicating that further engineering is needed to achieve complete breakdown.
Both wild-type and engineered bacterial strains were characterized, demonstrating that microbial engineering can expand the natural capacity to process lignin-derived chemical mixtures.