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Expanding genetic regulatory and efflux mechanisms for improved polymyxin production in Paenibacillus polymyxa.
PubMed · 2026-03-29
Researchers engineered a soil bacterium that naturally protects plant roots to produce far more of an antibiotic compound called polymyxin, using cheap agricultural waste as feed stock. A single protein tweak boosted output by 25% even on low-cost sugarcane molasses and cellulose scraps.
1
A single amino acid swap (T38W) in the efflux transporter PmxD boosted polymyxin P production nearly fourfold over wild-type in lab conditions.
2
Deleting transporter genes pmxCD cut polymyxin P output by roughly 50%, confirming the transporter's role in secretion.
3
Using a low-cost medium of cellulose hydrolysate and sugarcane molasses, the engineered strain produced 87.66 mg/L vs. 70.31 mg/L in the control, a 24.68% titer improvement.
