recombinant-proteins

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A synthetic expression system for orthogonal gene expression in Nicotiana benthamiana.

PubMed · 2026-06-02

Researchers built a synthetic genetic 'volume knob' for plants that controls how much of any target protein a plant produces — and it outperforms the industry-standard tool, the CaMV 35S promoter, in both strength and consistency.

The synthetic expression system (SES) produced higher and more stable RNA transcript levels than the widely used CaMV 35S promoter in all tested conditions

SES functioned without needing p19, a helper protein typically required to prevent plant immune silencing of foreign genes in transient expression experiments

SES successfully drove high-level accumulation of four distinct proteins — mCherry, glucose oxidase, protein A, and human VEGF165 — and remained functional in both plant and fungal hosts

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