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Probiotic yeast calms brain inflammation and shields memory neurons in rats

OpenAlex · 2026-12-01

A probiotic yeast called Saccharomyces boulardii reduced brain inflammation and protected memory-related neurons in rats exposed to a toxin that mimics Alzheimer's disease conditions. It did this by dampening inflammatory signals in the hippocampus, likely through the gut-brain axis rather than by blocking the initial inflammation trigger.

1

Saccharomyces boulardii pre-treatment significantly reduced NF-κB and IL-1β protein levels in the hippocampus of LPS-treated rats

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Probiotic treatment protected neurons in the hippocampal CA1 region from LPS-induced cell death, confirmed by Nissl staining

3

Sb partially improved spatial learning deficits but acted downstream of the TLR4 receptor, not by blocking TLR4 directly

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