Scientists found two genes in tobacco plants that actually make bacterial infections worse, and turning them off cut disease damage nearly in half while slashing the amount of pathogen in the plant several-fold.
1
Tobacco defense against Pseudomonas syringae unfolds in two phases: early stress/hormone signaling (12-24 hours post-infection) followed by metabolic remodeling (48-60 hours post-infection)
2
Silencing WRKY6 and WRKY23 genes reduced lesion area by 42-58% and pathogen load by 3.2-4.5 fold, revealing them as negative regulators of disease resistance
3
Phenylpropanoid metabolism, including L-phenylalanine and its derivative xanthosine, along with sphingolipid metabolism and light responses, were identified as key defense pathways
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