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Nuclear basket localized proteasomes maintain circadian period through nuclear TOC1 proteolysis
bioRxiv · 2026-05-23
Scientists discovered that special proteins at the nuclear pore — the cell's gatekeeper between nucleus and cytoplasm — help plants keep accurate 24-hour biological clocks by controlling the breakdown of a key clock protein called TOC1.
1
Mutant Arabidopsis plants lacking NUA or NUP136 nuclear basket proteins show significantly longer circadian periods than wildtype plants.
2
NUP136 physically recruits both the clock protein TOC1 and proteasome (cellular recycling machinery) components to the inner nuclear rim, forming a degradation complex.
3
Loss of NUP136 or NUA causes aberrant accumulation of TOC1 in the nucleus, directly linking nuclear pore basket function to circadian period length.