nuclear-pore

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Nuclear basket localized proteasomes maintain circadian period through nuclear TOC1 proteolysis

bioRxiv · 2026-05-23

Scientists discovered that special proteins at the nuclear pore — the cell's gatekeeper between nucleus and cytoplasm — help plants keep accurate 24-hour biological clocks by controlling the breakdown of a key clock protein called TOC1.

Mutant Arabidopsis plants lacking NUA or NUP136 nuclear basket proteins show significantly longer circadian periods than wildtype plants.

NUP136 physically recruits both the clock protein TOC1 and proteasome (cellular recycling machinery) components to the inner nuclear rim, forming a degradation complex.

Loss of NUP136 or NUA causes aberrant accumulation of TOC1 in the nucleus, directly linking nuclear pore basket function to circadian period length.

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nuclear-pore

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