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Engineered mRNA makes infected cells self-destruct on cue
PubMed · 2026-07-20
Scientists engineered a modified mRNA that reprograms virus-infected human cells to self-destruct the moment a specific viral protein is detected, stopping infections like hepatitis A, Zika, and COVID-19 in their tracks while alerting the immune system to mop up.
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LNP-delivered VIDA mRNA abolished hepatitis A virus replication and shedding in vivo and reduced liver injury
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The platform also worked against Zika virus and SARS-CoV-2, showing versatility across unrelated virus families
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Generative AI was used to design de novo cleavage motifs for the SARS-CoV-2 main protease, yielding VIDAs with improved antiviral potency