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Mouse study links RNA tagging to blood stem cell iron uptake
PubMed · 2026-08-20
Scientists found that a molecular tag on transfer RNA helps developing blood stem cells absorb enough iron to stay healthy; without it, cells can't make a key iron-uptake protein and suffer DNA damage. This is animal biology research on mouse liver stem cells, unrelated to plants.
1
Loss of the Trmt61a enzyme reduced m1A RNA modification and broadly lowered protein translation efficiency in mouse fetal liver blood stem cells
2
Ribosomes stalled at arginine-CGG codons in the Tfrc (transferrin receptor) mRNA, suppressing production of this iron-uptake protein
3
Resulting iron deficiency triggered DNA damage and impaired survival of hematopoietic stem and progenitor cells