Researchers found 38 reliable spots in the genome of a tiny heat-loving red alga where new genes can be inserted and work equally well. That removes a major guessing game for engineering algae to make useful compounds like isoprene, a building block for rubber and fuels.
1
Mapped 40 candidate neutral intergenic sites across 16 of 20 chromosomes in C. merolae, and validated 38 through robotic-assisted transformation.
2
Reporter gene expression was highly uniform across all integration sites and large populations of transformants, showing minimal positional effects.
3
Single-copy integrants produced comparable isoprene from a heterologous isoprene synthase regardless of genome position, measured with photobioreactors coupled to headspace analysis.
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