Gut bacteria from exercise-trained mice produce metabolites that protect muscles from wasting, even in mice that never exercised. Oral doses of two of those metabolites reduced muscle loss and preserved muscle function, positioning them as potential stand-ins for physical activity.
1
Gut content transfers from exercise-trained donor mice reduced hindlimb muscle atrophy in immobilized sedentary recipients compared with sedentary donors
2
Oral administration of pipecolic acid and succinate attenuated muscle atrophy and preserved muscle function in exercise-naive mice
3
Untargeted metabolomics confirmed both metabolites were enriched in cecal contents, serum, and muscle tissue consistent with microbial origin rather than host synthesis
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