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Chloroplast Genome Editing Eliminates Gluten Immunogenicity in Triticum aestivum

PubMed · 2026-02-20

Scientists used gene editing to remove nearly all the proteins in bread wheat that trigger celiac disease, while keeping the wheat's baking properties intact and field yields essentially unchanged.

1

Gene editing reduced harmful immunogenic proteins in bread wheat by 97%, nearly eliminating the celiac disease trigger.

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Immune cells from celiac disease patients showed no reaction when exposed to flour from the edited wheat lines.

3

Field crop yields from edited wheat were within 2% of unmodified wheat, confirming no meaningful agricultural trade-off.

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