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Immune proteins inside cells may drive human aging

PubMed · 2026-07-29

This paper is about how a part of the human immune system works inside cells to speed up aging and age-related diseases like dementia and kidney failure. It's a biomedical review with no connection to plants, crops, or gardening.

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Intracellular complement proteins C3 and C5 interact with core aging pathways including mTOR, NF-κB, and AMPK

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Intracellular C3 dysregulation is linked to organ-specific aging effects across the brain, liver, eye, kidney, vasculature, lung, immune system, and cancer

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Proposed therapeutic approaches include complement inhibitors, senolytics, RNA interference, and PROTACs, but compartment-specific tools and conditional knockout models are still lacking

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