Exosome-like nanovesicles from acerola for CRISPR-Cas9 ribonucleoprotein delivery to the central nervous system.
Scientists harvested tiny bubble-like particles naturally produced by the acerola fruit and used them to deliver CRISPR gene-editing tools into the brains of living animals via a nose spray. The plant-derived particles successfully edited a gene linked to ALS and frontotemporal dementia, suggesting a noninvasive route around the brain's toughest biological barrier.